Citation Information :
Sethi N, Vijay MK, Mathur A, Goyal S, Bansal S, Sharma M, Puniya A, Sharma S. Colonic Mixed Neuroendocrine Nonneuroendocrine Neoplasm: Two Case Reports with Brief Review of Literature. J Mahatma Gandhi Univ Med Sci Tech 2024; 9 (1--3):1-5.
Mixed neuroendocrine nonneuroendocrine neoplasms (MiNEN) are a heterogeneous subgroup of rare neoplasms. The present study describes two cases: the first case of an 82-year-old male with complaints of chronic constipation, loss of appetite, and weight loss in the last 6 months, with a history of bleeding per rectum; and the second case of a 45-year-old female with complaints of loss of appetite, chronic constipation, and weight loss for the past 4 months. A contrast-enhanced computed tomography (CECT) of the whole abdomen for the first case revealed irregular mural thickening involving the lower aspect of the descending colon and its junction with the sigmoid colon, while the second case showed circumferential mural thickening involving the mid-third of the transverse colon with mild submucosal edema involving the cecum and ascending colon. Right hemicolectomy and transverse hemicolectomy were performed, respectively, and histopathological findings of the resected specimens revealed them to be mixed neuroendocrine carcinoma with a nonneuroendocrine component (adenocarcinoma) (MiNEN). For the first case, immunohistochemically, the neuroendocrine tumor (NET) showed synaptophysin positivity and a 70% Ki-67 index, which indicates small cell carcinoma. For the second case, immunohistochemistry (IHC) of the tumor revealed positivity for cytokeratin, synaptophysin, chromogranin A, and SATB2, while the monoclonal antibody to Ki-67 (MIB) labeling index was 30%. The prognosis of colorectal MiNEN is the poorest compared with adenocarcinoma and neuroendocrine carcinoma.
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