Journal of Mahatma Gandhi University of Medical Sciences and Technology

Register      Login

VOLUME 7 , ISSUE 2 ( May-August, 2022 ) > List of Articles


Association of Chest Computed Tomography Severity Score with Oxygen Requirement D-dimer CRP and Comorbidities in Patients with COVID-19 Infection

Mukesh K Sarna, Pradeep Agarwal, Manish R Pahadia, Sudha Sarna, Kishore Moolrajani, Shail D Upadhyaya

Keywords : COVID-19, CT severity score, Hypoxia, SpO2, SARS-CoV-2

Citation Information : Sarna MK, Agarwal P, Pahadia MR, Sarna S, Moolrajani K, Upadhyaya SD. Association of Chest Computed Tomography Severity Score with Oxygen Requirement D-dimer CRP and Comorbidities in Patients with COVID-19 Infection. J Mahatma Gandhi Univ Med Sci Tech 2022; 7 (2):39-43.

DOI: 10.5005/jp-journals-10057-0197

License: CC BY-NC 4.0

Published Online: 27-02-2023

Copyright Statement:  Copyright © 2022; The Author(s).


Objective: Chest CT has higher sensitivity in comparison to reverse transcription-polymerase chain reaction (RT-PCR) for COVID-19 diagnosis. We aim to identify the association of CT severity scores (CTSS) with lab markers and the need for oxygen. Methods: Cross-sectional observational study of 104 COVID-19 RT-PCR positive hospitalized patients. Patients underwent pulmonary CT, and their CTSS was calculated. SpO2, D-dimer and C-reactive protein (CRP) were also measured. The data was then collected and analyzed. Results: CT Severity Score (CTSS) was higher in patients above 50 years of age and males, though statistically insignificant. CTSS was positively correlated with D-dimer (p = 0.048) and oxygen requirement (0.000). However, HbA1C was lower in patients with higher CTSS. Conclusion: High CTSS correlates well with oxygen requirement, low SpO2, and high D-dimer but not with CRP and HbA1C. Our data suggest that CTSS can help predict disease outcomes by assessing disease severity.

  1. WHO, Geneva, Switzerland: source/coronaviruse/situation–reports/20200121–sitrep–1–2019–ncov.pdf?sfvrsn=20a99c10 4. [Accessed 21 January 2020] Novel coronavirus (2019–nCoV) situation report — 1; 2020.
  2. WHO, Geneva, Switzerland: pdf?sfvrsn=72fa1b16 2. [Accessed 9 June 2020] Coronavirus disease 2019 (COVID-19) Situation report — 141; 2020.
  3. Fang Y, Zhang H, Xie J, et al. Sensitivity of chest CT for COVID-19: comparison to RT-PCR. Radiology 2020;296(2):E115–E117. DOI: 10.1148/radiol.2020200432
  4. Yang W, Cao Q, Qin L, et al. Clinical characteristics and imaging manifestations of the 2019el coronavirus disease (COVID-19): a multi-centre study in Wenzhou city, Zhejiang, China. J Infect 2020;80(4):388–393. DOI: 10.1016/j.jinf.2020.02.016
  5. Cheng Z, Lu Y, Cao Q, et al. Clinical features and chest CT manifestations of coronavirus disease 2019 (COVID-19) in a single-centre study in Shanghai, China. AJR Am J Roentgenol 2020;215(1):1–6. DOI: 10.2214/AJR.20.22959
  6. Salehi S, Abedi A, Balakrishnan S, et al. Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 patients. AJR Am J Roentgenol 2020;215(1):87–93. DOI: 10.2214/ AJR.20.23034
  7. Ye Z, Zhang Y, Wang Y, et al. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. Eur Radiol 2020;30(8):4381–4389. DOI: 10.1007/s00330-020-06801-0
  8. Ali TF, Tawab MA, ElHariri MA. CT chest of COVID-19 patients: what should a radiologist know?. Egypt J Radiol Nucl Med 2020;51(1):1–6. DOI: 10.1186/s43055-020-00245-8
  9. Ran Y, Xiang Li, Huan L, et al. Chest CT severity score: an imaging tool for assessing severe COVID-19. Radiol Cardiothoracic Imaging 2020;2(2):e200047. DOI: 10.1148/ryct.2020200047
  10. Saeed GA, Gaba W, Shah A, et al. Correlation between chest CT severity scores and the clinical parameters of adult patients with COVID-19 pneumonia. Radiol Res Pract 2021;2021:6697677. DOI: 10.1155/2021/6697677
  11. Zhao W, Zhong Z, Xie X, et al. Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: a multicentre study. AJR Am J Roentgenol 2020;214(5):1072–1077. DOI: 10.2214/AJR.20.22976
  12. Francone M, Iafrate F, Masci GM, et al. Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis. Eur Radiol 2020;30(12):6808–6817. DOI: 10.1007/s00330-020-07033-y
  13. Li K, Wu J, Wu F, et al. The clinical and chest CT features associated with severe and critical COVID-19 pneumonia. Invest Radiol 2020;55(6):327–331. DOI: 10.1097/ rli.0000000000000672
  14. Xiong Y, Sun D, Liu Y, et al. Clinical and high-resolution CT features of the COVID-19 infection: comparison of the initial and follow-up changes. Invest Radiol 2020;55(6):332–339. DOI: 10.1097/RLI.0000000000000674
  15. Zhichao F, Qizhi Y, Shanhu Y, et al. Early prediction of disease progression in COVID-19 pneumonia patients with chest CT and clinical characteristics. Nat Commun 2020;11(1):4968. DOI: 10.1038/s41467-020-18786-x
  16. Aalinezhad M, Alikhani F, Akbari P, et al. The Relationship between CT severity score and capillary blood oxygen saturation in patients with COVID-19 infection. Indian J Crit Care Med 2021;25(3):279–283. DOI: 10.5005/jp-journals-10071-23752
  17. Xie J, Covassin N, Fan Z, et al. Association between hypoxemia and mortality in patients with COVID-19. Mayo Clin Proc 2020;95(6):1138–1147. DOI: 10.1016/j.mayocp.2020.04.006
  18. Yilmaz A, Sabirli R, Seyit M, et al. Association between laboratory parameters and CT severity in patients infected with Covid-19: a retrospective, observational study. Am J Emerg Med 2021;42:110–114. DOI: 10.1016/j.ajem.2021.01.040
  19. Ejaz H, Alsrhani A, Zafar A, et al. COVID-19 and comorbidities: deleterious impact on infected patients. J Infect Public Health 2020;13(12):1833–1839. DOI: 10.1016/j.jiph.2020.07.014
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.