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VOLUME 7 , ISSUE 1 ( January-April, 2022 ) > List of Articles

RESEARCH ARTICLE

Correlation of Vitamin B12 Levels with Degree of Thrombocytopenia in Dengue Patients

Hari Prasad Paliwal, Chakrapani Mittal, Anchin Kalia, Mukesh Jain, Shrikant Choudhary, Puneet Rijhwani, Sumeet Garg

Keywords : Dengue, Platelet count, Vitamin B12

Citation Information : Paliwal HP, Mittal C, Kalia A, Jain M, Choudhary S, Rijhwani P, Garg S. Correlation of Vitamin B12 Levels with Degree of Thrombocytopenia in Dengue Patients. J Mahatma Gandhi Univ Med Sci Tech 2022; 7 (1):1-3.

DOI: 10.5005/jp-journals-10057-0190

License: CC BY-NC 4.0

Published Online: 31-08-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Introduction: Dengue fever, commonly known as breakbone fever is the most common arboviral mosquito-borne disease in the world. Aims of the study was to find any correlation of vitamin B12 levels with the degree of thrombocytopenia in dengue patients. Materials and methods: A hospital-based study from January 2019 to June 2020 at the Department of General Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur. The study was done on dengue fever patients with severe thrombocytopenia (<50,000 μL and >2 days duration). Results: Mean platelet count in patients with ≤200 pg/mL vitamin B12 was 38,653.06 ± 6362.49 per mL and in patients with >200 pg/mL vitamin B12 was 40,564.35 ± 61.04.78 per mL. Mean platelet recovery in patients with ≤200 pg/mL vitamin B12 was 7.00 ± 1.04 days and in patients with >200 pg/mL vitamin B12 was 4.33 ± 0.59 days. Mean hospital stay in patients with ≤200 pg/mL vitamin B12 was 7.96 ± 0.71 days and in patients with >200 pg/mL, vitamin B12 was 4.49 ± 0.50 days. Conclusion: Vitamin B12 deficiency may be a contributing factor to the development of severe thrombocytopenia in dengue fever, particularly in the Indian population. Vitamin B12 deficiency may prolong the hospital stay and increase the platelet recovery time.

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  1. World health Organization. Dengue and dengue haemorrhagic fever. Fact Sheet. No. 117, 2002. Available from: http//www.who.int/mediacentre/factsheets/fs117/en/.
  2. How Is Thrombocytopenia Diagnosed?-NHLBI, NIH. Www.nhlbi.nih.gov. Retrieved 2015-05-19.
  3. Smit-Sibinga CTh. Neonatology and Blood Transfusion. Springer Science & Business Media, 2010. ISBN 9780387236001.
  4. Tak S, Chachappan G, Rathore JS, et al. Severe thrombocytopenia in dengue fever and vitamin B12 level. J Assoc Physicians India 2018;66(9):61–63. https://www.japi.org/s2a49494/severe-thrombocytopenia-in-dengue-fever-and-vitamin-b12-level
  5. Dash PK, Sharma S, Srivastava A, et al. Emergence of dengue virus type 4 (genotypeI) in India. Epidemiol Infect 2011;139(6):857–861. DOI: 10.1017/S0950268810001706
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