Journal of Mahatma Gandhi University of Medical Sciences and Technology

Register      Login

VOLUME 3 , ISSUE 3 ( September-December, 2018 ) > List of Articles


Study of Serum Creatinine Level in Hypothyroidism

Dileep S Nirwan

Keywords : Autoimmune diseases, Hypercreatininemia, Hypothyroidism, Thyroid hormones

Citation Information : Nirwan DS. Study of Serum Creatinine Level in Hypothyroidism. J Mahatma Gandhi Univ Med Sci Tech 2018; 3 (3):79-81.

DOI: 10.5005/jp-journals-10057-0083

License: CC BY-NC 4.0

Published Online: 01-08-2020

Copyright Statement:  Copyright © 2018; The Author(s).


Background: Hypothyroidism is associated with many biochemical abnormalities. Many studies were done abroad regarding serum creatinine levels in hypothyroid patients. We designed this study in our population to evaluate serum creatinine levels in hypothyroid patients. Objective: To assess serum creatinine levels in hypothyroid patients and to find out the relationship of creatinine levels with the severity of hypothyroidism. Materials and methods: This is a retrospective cross-sectional study that aims to evaluate the serum creatinine levels of hypothyroid patients and to find out the relationship between hypercreatininemia and severity of hypothyroidism. The study was done in the Department of Biochemistry, PDU Medical College and attached group of hospitals, Churu, western Rajasthan. Results were compared with that of age- and sex-matched healthy euthyroid controls. Statistical analyses were done by using the SPSS version 16.0. ANOVA and unpaired t tests were done to see the significance among the groups and between groups, respectively. The Pearson's correlation coefficient test was done to see the correlation of serum creatinine with the severity of hypothyroidism. Results: Mean serum creatinine levels in cases were 0.922 ± 0.16 compared to 0.798 ± 0.098 mg/dL in controls. Conclusion: Mean serum creatinine levels were found significantly higher in hypothyroid patients compared to controls. These findings suggest that hypercreatininemia is associated with hypothyroidism. Therefore, patients presenting with this biochemical abnormality are recommended to be investigated to explore hypothyroidism.

  1. Greenspan FS. The thyroid gland. In: Greenspan FS, Gardner DG, ed. Basic & Clinical Endocrinology, 7th ed. New York: The McGraw-Hill Companies; 2004. pp. 215–294.
  2. Liberopoulos EN, Elisaf MS. Dyslipidemia in patients with thyroid disorders. Hormones (Athens) 2002;1(4):218–223. DOI: 10.14310/horm.2002.1170.
  3. Duntas LH. Thyroid disease and lipids. Thyroid 2002;12(4):287–293. DOI: 10.1089/10507250252949405.
  4. Walker BR, Toft AD. Endocrine disease. In: Haslett C, Chilvers ER, Boon NA, et al., ed. Davidson's principles and practice of medicine, 19th ed. London: Churchill Livingstone; 2002. pp. 683–746.
  5. Jameson JL, Weetman AP. Disorders of the thyroid gland. In: Braunwald E, Fauci AS, Kasper DL, et al., ed. Harrison's principles of internal medicine, 15th ed., New York: McGraw-Hill; 2001. pp. 2060–2084.
  6. Granner DK. Thyroid hormones. In: Murray RK, Granner DK, Mayes PA, et al., ed. Harper's biochemistry, 25th ed., Stamford: Appleton & Lange; 2000. pp. 561–566.
  7. Karanikas G, Schutz M, Szabo M, et al. Isotopic renal function studies in severe hypothyroidism and after thyroid hormone replacement therapy. Am J Nephrol 2004;24(1):41–45. DOI: 10.1159/000075628.
  8. Chaudhury HS, Raihan KK, Uddin MN, et al. Renal function impairment in hypothyroidism. Bangladesh J Med Biochem 2013;6(1):19–25. DOI: 10.3329/bjmb.v6i1.13283.
  9. Rashead QA, Hamid DM. The effect of thyroid hormone on some biochemical factors of kidney. Int J Adv Res 2015;3(7):290–297.
  10. Tejomani M, Meera KS, Vasudha KC. Relevance of creatine kinase activity and serum creatinine levels in hypothyroidism. Int J Recent Trends Sci Technol 2013;8(3):263–269.
  11. Jayagopal V, Keevil BG, Atkin SL, et al. Paradoxical changes in cystatin C and serum creatinine in patients with hypo and hyperthyroidism. Clin Chem 2003;49(4):680–681. DOI: 10.1373/49.4.680.
  12. Tayal D, Chawla R, Arora S, et al. Dynamic changes in biochemical markers of renal function with thyroid status – a study in Indian population. Int J Med Update 2009;4(2):36–41.
  13. Sinisa S, Daniela PG, Todor G, et al. Impact of thyroid dysfunction on serum cystatin C, serum creatinine and glomerular filtration rate. Maced J Med Sci 2011;4(1):25–30.
  14. Mamatha BV, Rakshitha MN, Kashinath RT, et al. Evaluation of serum urea and creatinine levels in subclinical hypothyroidism – a case control study. Med Innovatica 2016;5(2):3–6.
  15. Jia D, Liang LB, Tang GH, et al. The association between serum uric acid and creatinine in patients with hypothyroidism. Sichuan Da Xue Xue Bao Yi Xue Ban 2015;46(5):747–749.
  16. Kaur V, Singh K, Verma M. Changes in biochemical markers of renal function in subclinical and overt hypothyroidism. Int J Bioassays 2015;4(04):3799–3802.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.