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VOLUME 2 , ISSUE 2 ( 2017 ) > List of Articles

RESEARCH ARTICLE

Role of Lipid Profile in the Assessment of Nonalcoholic Steatohepatitis in Prediabetic and Diabetic Patients with Nonalcoholic Fatty Liver Disease

Bushra Fiza, Maheep Sinha, Lokesh Jain

Keywords : Dyslipidemia, Insulin resistance, Lipid profile, Nonalcoholic fatty liver disease, Nonalcoholic steatohepatitis

Citation Information : Fiza B, Sinha M, Jain L. Role of Lipid Profile in the Assessment of Nonalcoholic Steatohepatitis in Prediabetic and Diabetic Patients with Nonalcoholic Fatty Liver Disease. J Mahatma Gandhi Univ Med Sci Tech 2017; 2 (2):81-84.

DOI: 10.5005/jp-journals-10057-0041

License: CC BY-NC-ND 3.0

Published Online: 01-08-2018

Copyright Statement:  Copyright © 2017; The Author(s).


Abstract

Nonalcoholic fatty liver disease (NAFLD) is a chronic condition ranging from simple steatosis and fatty liver to more severe manifestations like nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Excess fat deposition is common in NAFLD and it is strongly correlated with insulin resistance and associated conditions, such as obesity, metabolic syndrome, type II diabetes mellitus, or hyperglycemic conditions. Most people with NAFLD remain asymptomatic until development of irrever­sible damage of liver tissue. The present study was planned to study the role of lipid profile in assessment of NASH in prediabetic and diabetic patients with NAFLD. Prediabetic (n = 100) and diabetic (n = 100) patients with NAFLD were enrolled for the study. Of the total 200 patients, 16% confirmed for NASH. Serum cholesterol > 200 mg/dL, triglycerides > 150 mg/dL, and high-density lipoprotein (HDL) < 60 mg/dL exhibited a strong association with occurrence of NASH. The study demonstrated that increased cholesterol (p = 0.000) and triglyceride (p = 0.009) and low HDL (p = 0.006) were significant markers in NASH patients. The study therefore recommends that prediabetic and diabetic patients with NAFLD should be regularly screened for lipid levels and patients with dyslipidemia should be considered to be at risk of developing NASH. Early identification of the disease can be helpful in providing timely treatment. How to cite this article Kumar A, Fiza B, Jain L, Kasliwal R, Sinha M. Role of Lipid Profile in the Assessment of Nonalcoholic Steatohepatitis in Prediabetic and Diabetic Patients with Nonalcoholic Fatty Liver Disease. J Mahatma Gandhi Univ Med Sci Tech 2017;2(2):81-84.

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