Study of Production of Alloantibodies in Multiple Transfused Thalassemia Patients in Pediatric Age Group
Jitendra K Gupta, Usha Acharya
Alloantibodies, Direct Coomb test, Multiple transfusion, Thalassemia major
Citation Information :
Gupta JK, Acharya U. Study of Production of Alloantibodies in Multiple Transfused Thalassemia Patients in Pediatric Age Group. J Mahatma Gandhi Univ Med Sci Tech 2017; 2 (3):118-121.
Thalassemia is a heterogeneous group of genetic disorders in which blood transfusion is life saving for thalassemia patients. Repeated transfusion causes multiple unexpected antibodies other than anti-A or B.
To detect and subtype the irregular antibodies in sera of thalassemia patients in Jaipur.
Materials and methods
A total of 100 patients of proven thalassemia were included in the study at Mahatma Gandhi Medical College and Hospital and JK Lon Hospital, Jaipur, Rajasthan, India. Information on transfusion history was recorded, 5 mL of blood was collected from each subject, and plasma was separated. These samples were subjected to direct Coomb's test (DCT) by column gel agglutination (CGA) technique.
In the present study, the alloantibodies which were most common among the seven positive samples out of 100 are anti-D, anti-K, anti-E, and anti-MN, with an incidence of 28.57, 28.57, 28.57, and 14.3% respectively. Blood group O had maximum number of alloantibodies (57%). According to number of transfusions, alloantibodies of thalassemia major patients showed statistically significant increase with increase in number of transfusion.
From the current study, it can be concluded that alloantibodies to minor group antigens are more frequent among thalassemia patients, which need more frequent blood transfusions.
How to cite this article
Gupta JK, Kumar P, Acharya U. Study of Production of Alloantibodies in Multiple Transfused Thalassemia Patients in Pediatric Age Group. J Mahatma Gandhi Univ Med Sci Tech 2017;2(3):118-121.
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