Diarrhea disease is caused by multipathogens and multifactors. It is widespread all over the world, and not only threatens human health but also greatly affects society and economy. Formulations that restrain two or more than two herbs are called polyherbal formulations. Drug formulation in Ayurveda is based on two principles: use as a single drug and use of more than one drug. The last is known as polyherbal formulation. The idea of polyherbalism is peculiar to Ayurveda even though it is tricky to explain in terms of modern parameters. The Ayurvedic literature Sarangdhar Samhita tinted the idea of polyherbalism to attain greater therapeutic efficacy. Polyherbal formulations have been used all around the earth due to their medicinal and therapeutic application. It has also been recognized as polyherbal therapy or herb–herb combination. The active phytochemical constituents of individual plants are inadequate to attain the desirable therapeutic effects. When polyherbal and herbo-mineral formulations combined with the multiple herbs in a meticulous ratio, it will give an enhanced therapeutic effect and decrease the toxicity. The active constituents used from individual plants are inadequate to provide attractive pharmacological action. There are evidences that crude plant extracts often have greater potency rather than isolated constituents. In traditional medicine, whole plants or mixtures of plants are used rather than isolated compounds. Due to synergism, polyherbalism confers some benefits which are not accessible in single herbal formulations. Polyherbal formulations express high effectiveness in numerous diseases with safe high doses. Plants and their products have been used by humans for treatments of numerous diseases for thousands of years. Traditional medicine (also known as indigenous or folk medicine) comprises knowledge that developed over generations within various societies before the era of modern medicine. Natural products derived from medicinal plants have proven to be an abundant source of biologically active compounds. The main focus of this review paper is to develop alternate natural ecofriendly herbal formulations to treat diarrheal diseases.