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VOLUME 7 , ISSUE 2 ( May-August, 2022 ) > List of Articles


Metronidazole-induced Cerebellar Ataxia: A Rare Presentation

Shikha Yadav, Deepak Gupta, Anchin Kalia, Anil Panwar, Yudhishther Kuntal, Naveen Yadav, Navin Chhaba, Pushpendra Chauhan, Manjeet Manjet, Pruthvi Patel, Vaishali Sharai, Piyush Batra

Keywords : Ataxia, Cerebellum, Dentate nucleus, Metronidazole

Citation Information : Yadav S, Gupta D, Kalia A, Panwar A, Kuntal Y, Yadav N, Chhaba N, Chauhan P, Manjet M, Patel P, Sharai V, Batra P. Metronidazole-induced Cerebellar Ataxia: A Rare Presentation. J Mahatma Gandhi Univ Med Sci Tech 2022; 7 (2):57-58.

DOI: 10.5005/jp-journals-10057-0209

License: CC BY-NC 4.0

Published Online: 27-02-2023

Copyright Statement:  Copyright © 2022; The Author(s).


Metronidazole is an antibiotic and an antiprotozoal drug very commonly used in our day-to-day practice. It is generally well tolerated and common vomiting, abdominal cramps, and metallic taste. We are presenting a rare case of metronidazole-induced cerebellar ataxia in a patient who received the drug for a relatively shorter duration. The neurological features usually occur when the drug dose exceeds 2 gm/day for a prolonged period. Peripheral neuropathy, dizziness, encephalopathy, seizures, and optic neuropathy can be seen. Cerebellar ataxia is a rare and serious side effect of this drug.

  1. Goodman and Gilman's. The pharmacological basis of therapeutics. 13th edition.
  2. NS Neki, Joshi N, Rana D, et al. Metronidazole toxicity presenting with cerebellar ataxia. Int J Curr Res Med Sci 2017;3:10–13. DOI: 10.22192/ijcrms.2017.03.05.003
  3. Patel K, Green-Hopkins I, Lu S, et al. Cerebellar ataxia following prolonged use of metronidazole: case report and a literature review. Int J Infect Dis 2008;12(6):e111–e114. DOI: 10.1016/j.ijid.2008.03.006
  4. Ahmed A, Loes DJ, Bressler EL. Reversible magnetic resonance finding in metronidazole induced encephalopathy. Neurology 1995;45(3 Pt 1):588–589. DOI: 10.1212/wnl.45.3.588
  5. Chandak S, Aggarwal A, Shukla A, et al. A case report of metronidazole induced neurotoxicity in liver abscess patients and usefulness of MRI in its diagnosis. J Clin Diagn Res 2016;10(1):TD06–TD07. DOI: 10.7860/JCDR/2016/14900.7031
  6. Bradley WG, Karlason IJ, Rrasol CG. Metronidazole neuropathy. Br Med J 1977;2(6087):610–611. DOI: 10.1136/bmj.2.6087.610
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