Objective: Chest CT has higher sensitivity in comparison to reverse transcription-polymerase chain reaction (RT-PCR) for COVID-19 diagnosis. We aim to identify the association of CT severity scores (CTSS) with lab markers and the need for oxygen.
Methods: Cross-sectional observational study of 104 COVID-19 RT-PCR positive hospitalized patients. Patients underwent pulmonary CT, and their CTSS was calculated. SpO2, D-dimer and C-reactive protein (CRP) were also measured. The data was then collected and analyzed.
Results: CT Severity Score (CTSS) was higher in patients above 50 years of age and males, though statistically insignificant. CTSS was positively correlated with D-dimer (p = 0.048) and oxygen requirement (0.000). However, HbA1C was lower in patients with higher CTSS.
Conclusion: High CTSS correlates well with oxygen requirement, low SpO2, and high D-dimer but not with CRP and HbA1C. Our data suggest that CTSS can help predict disease outcomes by assessing disease severity.
Fang Y, Zhang H, Xie J, et al. Sensitivity of chest CT for COVID-19: comparison to RT-PCR. Radiology 2020;296(2):E115–E117. DOI: 10.1148/radiol.2020200432
Yang W, Cao Q, Qin L, et al. Clinical characteristics and imaging manifestations of the 2019el coronavirus disease (COVID-19): a multi-centre study in Wenzhou city, Zhejiang, China. J Infect 2020;80(4):388–393. DOI: 10.1016/j.jinf.2020.02.016
Cheng Z, Lu Y, Cao Q, et al. Clinical features and chest CT manifestations of coronavirus disease 2019 (COVID-19) in a single-centre study in Shanghai, China. AJR Am J Roentgenol 2020;215(1):1–6. DOI: 10.2214/AJR.20.22959
Salehi S, Abedi A, Balakrishnan S, et al. Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 patients. AJR Am J Roentgenol 2020;215(1):87–93. DOI: 10.2214/ AJR.20.23034
Ye Z, Zhang Y, Wang Y, et al. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. Eur Radiol 2020;30(8):4381–4389. DOI: 10.1007/s00330-020-06801-0
Ali TF, Tawab MA, ElHariri MA. CT chest of COVID-19 patients: what should a radiologist know?. Egypt J Radiol Nucl Med 2020;51(1):1–6. DOI: 10.1186/s43055-020-00245-8
Ran Y, Xiang Li, Huan L, et al. Chest CT severity score: an imaging tool for assessing severe COVID-19. Radiol Cardiothoracic Imaging 2020;2(2):e200047. DOI: 10.1148/ryct.2020200047
Saeed GA, Gaba W, Shah A, et al. Correlation between chest CT severity scores and the clinical parameters of adult patients with COVID-19 pneumonia. Radiol Res Pract 2021;2021:6697677. DOI: 10.1155/2021/6697677
Zhao W, Zhong Z, Xie X, et al. Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: a multicentre study. AJR Am J Roentgenol 2020;214(5):1072–1077. DOI: 10.2214/AJR.20.22976
Francone M, Iafrate F, Masci GM, et al. Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis. Eur Radiol 2020;30(12):6808–6817. DOI: 10.1007/s00330-020-07033-y
Li K, Wu J, Wu F, et al. The clinical and chest CT features associated with severe and critical COVID-19 pneumonia. Invest Radiol 2020;55(6):327–331. DOI: 10.1097/ rli.0000000000000672
Xiong Y, Sun D, Liu Y, et al. Clinical and high-resolution CT features of the COVID-19 infection: comparison of the initial and follow-up changes. Invest Radiol 2020;55(6):332–339. DOI: 10.1097/RLI.0000000000000674
Zhichao F, Qizhi Y, Shanhu Y, et al. Early prediction of disease progression in COVID-19 pneumonia patients with chest CT and clinical characteristics. Nat Commun 2020;11(1):4968. DOI: 10.1038/s41467-020-18786-x
Aalinezhad M, Alikhani F, Akbari P, et al. The Relationship between CT severity score and capillary blood oxygen saturation in patients with COVID-19 infection. Indian J Crit Care Med 2021;25(3):279–283. DOI: 10.5005/jp-journals-10071-23752
Xie J, Covassin N, Fan Z, et al. Association between hypoxemia and mortality in patients with COVID-19. Mayo Clin Proc 2020;95(6):1138–1147. DOI: 10.1016/j.mayocp.2020.04.006
Yilmaz A, Sabirli R, Seyit M, et al. Association between laboratory parameters and CT severity in patients infected with Covid-19: a retrospective, observational study. Am J Emerg Med 2021;42:110–114. DOI: 10.1016/j.ajem.2021.01.040
Ejaz H, Alsrhani A, Zafar A, et al. COVID-19 and comorbidities: deleterious impact on infected patients. J Infect Public Health 2020;13(12):1833–1839. DOI: 10.1016/j.jiph.2020.07.014