Introduction: COVID-19 epidemic caused by SARS-CoV-2 has progressed into a pandemic. The effect of the virus on healthcare workers (HCWs) is immense and they are one of the highest risk groups in terms of exposure to infection. This study was done to understand the severity of disease in HCWs when they do get infected by SARS-CoV-2 so that we can be better prepared for such future outbreaks of infections. Materials and methods: Healthcare workers affected by SARS COVID-19 infection were identified from March 2020 to December 2020, and a questionnaire regarding clinical profile, course of illness, source of infection, pre-exposure prophylaxis, CT value, CTSS score, vaccination-related information, etc., were collected and analyzed. Results: Out of 133 HCWs, 77.4% had mild disease, 18% had moderate disease, and 4.5% had severe disease. All patients with severe disease belonged to the 35–55 years age-group. About 64.4% of HCWs who had got an HRCT-chest done had a CT severity score of less than 8 out of 25, 60.1% HCWs were home quarantined only, 33% of those who required hospital admission were admitted for less than 15 days, 88.7% HCWs did not require any ventilatory supports, 9% of the HCWs were given plasma therapy, post hoc analysis (Bonferroni) indicated a significantly lower mean cycle threshold value (higher viral load) in severe disease than a mild disease in healthcare workers. Conclusion: There was no significant difference in the severity of distribution according to gender, prophylaxis, contact history, duration of hospital stay, ventilatory support, and receiving plasma therapy. CT severity scores positively correlated with disease severity in HCWs.