Journal of Mahatma Gandhi University of Medical Sciences and Technology

Register      Login

VOLUME 6 , ISSUE 2 ( May-August, 2021 ) > List of Articles


Effect of Oral Gabapentin and Pregabalin in the Management of Neuropathic Pain in Palliative Care Patients: An Institution-based Comparative Study

Keywords : Cancer, Gabapentin, Palliative care, Pregabalin

Citation Information : Effect of Oral Gabapentin and Pregabalin in the Management of Neuropathic Pain in Palliative Care Patients: An Institution-based Comparative Study. J Mahatma Gandhi Univ Med Sci Tech 2021; 6 (2):46-47.

DOI: 10.5005/jp-journals-10057-0151

License: CC BY-NC 4.0

Published Online: 31-08-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Background: Gabapentin and pregabalin are antiepileptic drugs used in the treatment of neuropathic pain. They are used as adjuvants with analgesics in the management of pain. Aims and objectives: We aimed to compare gabapentin and pregabalin's role in neuropathic pain in cancer patients. Materials and methods: This prospective, comparative study included 100 patients having neuropathic pain, undergoing cancer treatment in Mahatma Gandhi Hospital. Results: The mean age of patients was 38.2 ± 8.2 in the gabapentin group and 37.4 ± 7.4 in the pregabalin group. Headache was the most common among the gabapentin group, followed equally by placebo and pregabalin groups. Nausea was equally reported by the gabapentin and placebo groups. Dizziness was seen equally among the placebo and pregabalin groups followed by the gabapentin group. Conclusion: The study concluded that pregabalin is a better medication for the management of neuropathic pain as compared to gabapentin.

PDF Share
  1. Vadivelu N, Mitra S, Narayan D. Recent advances in postoperative pain management. Yale J Biol Med 2010;83(1):11–25.
  2. Sinatra R. Causes and consequences of inadequate management of acute pain. Pain Med 2010;11(12):1859–1871. DOI: 10.1111/j.1526-4637.2010.00983.x.
  3. Rodriguez MJ, Diaz S, Vera-Llonch M, et al. Cost-effectiveness analysis of pregabalin versus gabapentin in the management of neuropathic pain due to diabetic polyneuropathy or post-herpetic neuralgia. Curr Med Res Opin 2007;23(10):2585–2596. DOI: 10.1185/030079907X233151.
  4. Navarro A, Saldaña MT, Pérez C, et al. A cost-consequences analysis of the effect of pregabalin in the treatment of peripheral neuropathic pain in routine medical practice in primary care settings. BMC Neurol 2011;11(1):1. DOI: 10.1186/1471-2377-11-7.
  5. Saraswat V, Arora V. Preemptive gabapentin vs pregabalin for acute postoperative pain after surgery under spinal anaesthesia. Ind J Anaes 2008;52:829–834.
  6. Yilmaz B, Yasar E, Koroglu OO, et al. Gabapentin vs pregabalin for the treatment of neuropathic pain in patients with spinal cord injury: a crossover study. Turk J Phys Med Rehab 2014;61(1):1–5. DOI: 10.5152/tftrd.2015.79069.
  7. Richter RW, Portenoy R, Sharma U, et al. Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial. J Pain 2005;6(4):253–260. DOI: 10.1016/j.jpain.2004.12.007.
  8. Rosenstock J, Tuchman M, LaMoreaux L, et al. Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo controlled trial. Pain 2004;110(3):628–638. DOI: 10.1016/j.pain.2004.05.001.
  9. Lesser H, Sharma U, LaMoreaux L, et al. Pregabalin relieves symptoms of painful diabetic neuropathy A randomized controlled trial. Neurology 2004;63(11):2104–2110. DOI: 10.1212/01.wnl.0000145767.36287.a1.
  10. Mishra R, Tripathi M, Chandola HC. Comparative clinical study of gabapentin and pregabalin for postoperative analgesia in laparoscopic cholecystectomy. Anesth Essays Res 2016;10(2):201–206. DOI: 10.4103/0259-1162.176409.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.