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VOLUME 6 , ISSUE 2 ( May-August, 2021 ) > List of Articles

RESEARCH ARTICLE

Diabetes Mellitus as a Bad Prognostic Marker in COVID-19 Patients and Its Relationship with Inflammatory Markers (CRP, D-dimer, LDH, and Ferritin)

Aakriti Vij, Shrikant Choudhary, Chakrapani Mittal, Aviral Gupta, Kishore Moolrajani

Keywords : Coronavirus disease 2019, Diabetes mellitus, Outcome

Citation Information : Vij A, Choudhary S, Mittal C, Gupta A, Moolrajani K. Diabetes Mellitus as a Bad Prognostic Marker in COVID-19 Patients and Its Relationship with Inflammatory Markers (CRP, D-dimer, LDH, and Ferritin). J Mahatma Gandhi Univ Med Sci Tech 2021; 6 (2):42-45.

DOI: 10.5005/jp-journals-10057-0156

License: CC BY-NC 4.0

Published Online: 31-08-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Abstract

Background: Coronavirus disease 2019 (COVID-19) is a newly recognized illness that is spreading rapidly around the world, causing many disabilities and deaths. Some diseases, for instance, diabetes, are continuously suggested as a risk factor, which contribute to the severity and mortality of COVID-19. However, to date, there are no comprehensive studies done that are aimed at explaining the exact relationship between diabetes mellitus and COVID-19. Thus, this study aims to evaluate the relationship between diabetes and COVID-19 and its relationship with inflammatory markers. Materials and methods: This single-center retrospective observational study was conducted on 187 patients diagnosed with COVID-19. The data were collected on admission or during hospitalization by the attending physicians and was documented in the form of electronic medical records. The need for informed consent from patients was waived due to the time constraints during the COVID-19 emergency. Results: Of the 187 hospitalized patients with COVID-19, 50 patients had diabetes. The median age was 59 years and 35 (70.00%) were male. Common symptoms among all patients included fever (57.21%) and cough (48.13%). Patients with diabetes had a non-significantly higher LDH, ferritin, CRP, and D-dimer when compared with those without diabetes. Coronavirus disease 2019 patients with diabetes were significantly more likely to develop severe disease or suffer mortality, indicating a poorer prognosis among COVID-19 patients. Conclusion: We concluded that diabetes mellitus is associated with greater disease severity and poor outcome (mortality) in COVID-19, and a higher but statistically non-significant inflammatory burden.

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  1. Lai CC, Shih TP, Ko WC, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges. Int J Antimicrob Agents 2020;55(3):105924. DOI: 10.1016/j.ijantimicag.2020.105924.
  2. World Health Organization, WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020 [Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020.
  3. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382(18):1708–1720. DOI: 10.1056/NEJMoa2002032.
  4. Bai Y, Yao L, Wei T, et al. Presumed asymptomatic carrier transmission of COVID-19. JAMA 2020;323(14):1406–1407. DOI: 10.1001/jama.2020.2565.
  5. Xu Y, Li X, Zhu B, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med 2020;26(4):502–505. DOI: 10.1038/s41591-020-0817-4.
  6. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cxases from the Chinese center for disease control and prevention. JAMA 2020;323(13):1239–1242. DOI: 10.1001/jama.2020.2648.
  7. Han X, Fan Y, Wan YL, et al. A diabetic patient with 2019-nCoV (COVID-19) infection who recovered and was discharged from hospital. J Thorac Imaging 2020;35(3):W94–W95. DOI: 10.1097/RTI.0000000000000506.
  8. Rogers LC, Lavery LA, Joseph WS, et al. All feet on deck-the role of podiatry during the COVID-19 pandemic: preventing hospitalizations in an overburdened healthcare system, reducing amputation and death in people with diabetes. J Am Podiatr Med Assoc 2020. DOI: 10.7547/20-051.
  9. Knapp S. Diabetes and infection: is there a link?--a mini-review. Gerontology 2013;59(2):99–104. DOI: 10.1159/000345107.
  10. Hodgson K, Morris J, Bridson T, et al. Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections. Immunology 2015;144(2):171–185. DOI: 10.1111/imm.12394.
  11. Muller LMAJ, Gorter KJ, Hak E, et al. Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus. Clin Infect Dis 2005;41(3):281–288. DOI: 10.1086/431587.
  12. Yang JK, Feng Y, Yuan MY, et al. Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS. Diabet Med 2006;23(6):623–628. DOI: 10.1111/j.1464-5491.2006.01861.x.
  13. Guo W, Li M, Dong Y, et al. Diabetes is a risk factor for the progression and prognosis of COVID-19. Diabetes Metab Res Rev 2020(7):e3319. DOI: 10.1002/dmrr.3319.
  14. Williamson EJ, Walker AJ, Bhaskaran K, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature 2020;584(7821):430–436. DOI: 10.1038/s41586-020-2521-4.
  15. Team CC-R. Preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019 - United States, February 12-March 28, 2020. Morb Mortal Wkly Rep 2020;69(13):382–386. DOI: 10.15585/mmwr.mm6913e2.
  16. Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia - a systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr 2020;14(4):395–403. DOI: 10.1016/j.dsx.2020.04.018.
  17. Kenny GP, Sigal RJ, McGinn R. Body temperature regulation in diabetes. Temperature (Austin) 2016;3(1):119–145. DOI: 10.1080/23328940.2015.1131506.
  18. Wu J, Li W, Shi X, et al. Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID-19). J Intern Med 2020;288(1):128–138. DOI: 10.1111/joim.13063.
  19. Diao B, Wang C, Tan Y, et al. Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19). Front Immunol 2020;11:827. DOI: 10.3389/fimmu.2020.00827.
  20. Kulcsar KA, Coleman CM, Beck SE, et al. Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI Insight 2019;4(20):e131774. DOI: 10.1172/jci.insight.131774.
  21. Yang JK, Lin SS, Ji XJ, et al. Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol 2010;47(3):193–199. DOI: 10.1007/s00592-009-0109-4.
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