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VOLUME 5 , ISSUE 3 ( September-December, 2020 ) > List of Articles

Original Article

Clinical and Laboratory Profile of COVID-19 Patients Presenting to a Tertiary Care Hospital in Jaipur, Rajasthan: An Observational Study

Aviral Gupta

Keywords : C-reactive protein, Coronavirus disease 2019, Neutrophil:lymphocyte ratio

Citation Information : Gupta A. Clinical and Laboratory Profile of COVID-19 Patients Presenting to a Tertiary Care Hospital in Jaipur, Rajasthan: An Observational Study. J Mahatma Gandhi Univ Med Sci Tech 2020; 5 (3):91-95.

DOI: 10.5005/jp-journals-10057-0129

License: CC BY-NC 4.0

Published Online: 01-12-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: In this study, we aim to report the clinical and laboratory profile of 187 coronavirus disease 2019 (COVID-19) patients admitted to a tertiary care hospital in Jaipur, Rajasthan, India. Materials and methods: Case records were accessed retrospectively, and demographic profile, clinical presentation, and two laboratory markers [neutrophil:lymphocyte ratio (NLR) and C-reactive protein (CRP)] were evaluated in 187 patients with confirmed COVID-19 infection. Patients were divided into two groups for analysis—recovered/discharged group and mortality group. Results: In our study, the mortality rate was 11.8% (22 out of 187 cases) with similar age and sex distribution between the two groups. A higher proportion of patients in the mortality group had severe disease as compared to the recovered group (72.7 vs 8.5%). Patients who died had a longer mean duration of symptoms before admission (5.2 vs 3.3 days), with a lower duration of hospital admission (5.6 vs 10.6 days) as compared to the recovered group. Fourteen out of 22 patients in the mortality group required non-invasive or invasive ventilatory support at admission, compared to 21 out of 165 patients who recovered; and 86.4% of patients who died had comorbidities vs 43.6% of those who recovered. The mean NLR was over 3.5 times higher and mean CRP at admission nearly 2.6 times higher in the mortality group.


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  1. Kahn JS, McIntosh K. History and recent advances in coronavirus discovery. Pediatr Infect Dis J 2005;24(11 Suppl):S223–S227. DOI: 10.1097/01.inf.0000188166.17324.60, discussion S6.
  2. Donnelly CA, Ghani AC, Leung GM, et al. Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. Lancet 2003;361(9371):1761–1766. DOI: 10.1016/S0140-6736(03)13410-1.
  3. Cauchemez S, Fraser C, Van Kerkhove MD, et al. Middle east respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility. Lancet Infect Dis 2014;14(1):50–56. DOI: 10.1016/S1473-3099(13)70304-9.
  4. World Health Organization. WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020 11 February, 2020 [Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020.
  5. World Health Organization. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020 11 March 2020 [Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020.
  6. World Health Organization. Weekly Epidemiological Update Coronavirus disease 2019 (COVID-19) 21 September 2020 2020 [Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200921-weekly-epi-update-6.pdf?sfvrsn=d9cf9496_6.
  7. Chatterjee P. Is India missing COVID-19 deaths? Lancet 2020;396(10252):657. DOI: 10.1016/S0140-6736(20)31857-2.
  8. Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020;181(2):271–280.e8. DOI: 10.1016/j.cell.2020.02.052.
  9. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese center for disease control and prevention. JAMA 2020;323(13):1239–1242. DOI: 10.1001/jama.2020.2648.
  10. Singhal T. A review of coronavirus disease-2019 (COVID-19). Indian J Pediatr 2020;87(4):281–286. DOI: 10.1007/s12098-020-03263-6.
  11. Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, et al. Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis 2020;34:101623. DOI: 10.1016/j.tmaid.2020.101623.
  12. Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the new york city area. JAMA 2020;323(20):2052–2059. DOI: 10.1001/jama.2020.6775.
  13. Yang W, Cao Q, Qin L, et al. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): a multi-center study in Wenzhou city, Zhejiang, China. J Infect 2020;80(4):388–393. DOI: 10.1016/j.jinf.2020.02.016.
  14. Samaddar A, Gadepalli R, Nag VL, et al. The enigma of low COVID-19 fatality rate in India. Front Genet 2020;11:854. DOI: 10.3389/fgene.2020.00854.
  15. Du RH, Liang LR, Yang CQ, et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study. Eur Respir J 2020;55(5):2000524. DOI: 10.1183/13993003.00524-2020.
  16. Du Y, Tu L, Zhu P, et al. Clinical features of 85 fatal cases of COVID-19 from Wuhan. A retrospective observational study. Am J Respir Crit Care Med 2020;201(11):1372–1379. DOI: 10.1164/rccm.202003-0543OC.
  17. Yang AP, Liu JP, Tao WQ, et al. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol 2020;84:106504. DOI: 10.1016/j.intimp.2020.106504.
  18. Wang L. C-reactive protein levels in the early stage of COVID-19. Med Mal Infect 2020;50(4):332–334. DOI: 10.1016/j.medmal.2020.03.007.
  19. Ponti G, Maccaferri M, Ruini C, et al. Biomarkers associated with COVID-19 disease progression. Crit Rev Clin Lab Sci 2020;57(6):389–399. DOI: 10.1080/10408363.2020.1770685.
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