Background: Hypothyroidism is associated with many biochemical abnormalities. Many studies were done abroad regarding serum creatinine levels in hypothyroid patients. We designed this study in our population to evaluate serum creatinine levels in hypothyroid patients.
Objective: To assess serum creatinine levels in hypothyroid patients and to find out the relationship of creatinine levels with the severity of hypothyroidism.
Materials and methods: This is a retrospective cross-sectional study that aims to evaluate the serum creatinine levels of hypothyroid patients and to find out the relationship between hypercreatininemia and severity of hypothyroidism. The study was done in the Department of Biochemistry, PDU Medical College and attached group of hospitals, Churu, western Rajasthan. Results were compared with that of age- and sex-matched healthy euthyroid controls. Statistical analyses were done by using the SPSS version 16.0. ANOVA and unpaired t tests were done to see the significance among the groups and between groups, respectively. The Pearson\'s correlation coefficient test was done to see the correlation of serum creatinine with the severity of hypothyroidism.
Results: Mean serum creatinine levels in cases were 0.922 ± 0.16 compared to 0.798 ± 0.098 mg/dL in controls.
Conclusion: Mean serum creatinine levels were found significantly higher in hypothyroid patients compared to controls. These findings suggest that hypercreatininemia is associated with hypothyroidism. Therefore, patients presenting with this biochemical abnormality are recommended to be investigated to explore hypothyroidism.
Greenspan FS. The thyroid gland. In: Greenspan FS, Gardner DG, ed. Basic & Clinical Endocrinology, 7th ed. New York: The McGraw-Hill Companies; 2004. pp. 215–294.
Liberopoulos EN, Elisaf MS. Dyslipidemia in patients with thyroid disorders. Hormones (Athens) 2002;1(4):218–223. DOI: 10.14310/horm.2002.1170.
Duntas LH. Thyroid disease and lipids. Thyroid 2002;12(4):287–293. DOI: 10.1089/10507250252949405.
Walker BR, Toft AD. Endocrine disease. In: Haslett C, Chilvers ER, Boon NA, et al., ed. Davidson's principles and practice of medicine, 19th ed. London: Churchill Livingstone; 2002. pp. 683–746.
Jameson JL, Weetman AP. Disorders of the thyroid gland. In: Braunwald E, Fauci AS, Kasper DL, et al., ed. Harrison's principles of internal medicine, 15th ed., New York: McGraw-Hill; 2001. pp. 2060–2084.